Babies Dying from Drug Resistant Superbugs

Malawi (CNN) Baby Abigail was born prematurely at seven months in Chatinkha nursery in Queen Elizabeth Central Hospital in Blantyre, Malawi, Lilian Matchaya, her mother is worried: she weighed just 1.8 kilograms (3 pounds) at birth, little more than a bag of flour. She needed an injection of aminophylline, which dilates the lung’s cells, to help her breathe, and the day after her birth, nurses found her passed out with blood in her stool.

Babies, especially those born prematurely, are especially vulnerable to infection, as their immune systems haven’t developed properly. Doctors suspected that Abigail had sepsis, a serious and potentially fatal condition in which bacteria get into the bloodstream. In response, the body’s immune system goes into overdrive, and organs begin to shut down.
Abigail was given two antibiotics, penicillin and gentamicin, a combination meant to kill a wide range of bacteria. The drugs didn’t seem to work, and she was soon given ceftriaxone and metronidazole, but there was still no improvement.
Her medical notes state that she then became floppy and passed out once more.
Lab results revealed that she was infected with a drug-resistant form of Klebsiella. The bacteria were resistant to most of the drugs Abigail had been given, meaning the medications were not working to kill her infection.
For every hour that a baby in septic shock is given ineffective drugs, the chance of survival decreases by 7.6%, one study found. Dr. Kondwani Kawaza, a neonatologist at the Chatinkha nursery, said that even if the baby doesn’t die, sepsis can cause disabling complications such as brain damage, meningitis and impairment to vital organs like the kidneys and the liver.
Doctors at the hospital also face another problem: The antibiotics they needed to treat Abigail’s superbug are expensive and not part of Malawi’s standard drug regimen, meaning they’re not always available in the hospital.
On this occasion, Abigail was lucky: The pharmacy had one of the drugs they needed, amikacin, which can be given for only short periods, as it can trigger deafness as well as kidney and nerve damage.
Abigail was promptly given amikacin, after which her family faced a waiting game.
“The first thing I do when I wake up daily is to pray for my baby to get well. Then I check on her with the hope that she will be OK,” said Matchaya, a soft-voiced housewife, through an interpreter. She lives with her husband, a teacher, and three sons in Nancholi, on the outskirts of Blantyre.
Abigail Matchaya weighed just 3 pounds at birth, having been born prematurely, and soon developed sepsis.

Lilian Matchaya holds her daughter, Abigail, praying for her to get better.

According to Kawaza, 20% to 40% of infections his team diagnoses are now resistant to antibiotics. The proportion was a lot lower five years ago, he said.

A nation in crisis

Malawi is one of the poorest countries in the world, ranking 170th out of 188 on the United Nations’ human development index. More than 70% of its 18 million people survive on less than $1.90 a day, the international benchmark of poverty.
Most Malawians do not own televisions, cars or phones or have internet. In rural areas, people grow their own food.
And now, the country is facing an epidemic of infections causing sepsis, one of the leading causes of death among newborns. It killed nearly 20% of them in 2016; by comparison, in the UK, sepsis is responsible for less than 2% of infant deaths.
A combination of factors, all related to poverty, mean the percentage of babies dying of sepsis has barely fallen since 2000 despite improvements in the health care system.
CNN, ADAPTED

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